A new experimental formulation based on sugarcane could transform the treatment of dry mouth, a condition that significantly increases tooth fragility. Brazilian researchers have developed a solution inspired by the mouth's natural mechanisms, designed to strengthen enamel when saliva is no longer sufficient to provide its protective function.
A protective film tested in the laboratory
At the heart of this innovation is a protein derived from sugarcane, called CANECPI-5, developed by a team at the University of São Paulo. When deposited on the enamel, it forms a thin layer capable of limiting acid damage from food, drinks, and even gastric reflux. In the laboratory, a daily one-minute application as a mouthwash was sufficient to improve the resistance of the tooth surface on tested fragments.
Performance is enhanced when this protein is combined with two components already known for cavity prevention: fluoride and xylitol. The mixture acts on two fronts: it strengthens enamel protection while inhibiting bacterial activity responsible for demineralization.
This approach is of particular interest to patients whose saliva production is impaired, especially after intensive treatments such as head and neck radiotherapy. In these situations, dry mouth can accelerate cavities and infections. Initial tests indicate that the formulation limits the loss of essential minerals such as calcium and phosphate, while reducing harmful bacteria without disrupting the oral microbiota—a key factor for long-term use.
